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Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to brook trout
(salvelinus fontinalis) during early development
Walker, Mary K | Peterson, Richard E
Environmental Toxicology and Chemistry. Vol. 13, no. 5, pp.
817-820. 1994
The sensitivity of early life stages of brook trout (Salvelinus
fontinalis) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity
was investigated. Newly fertilized eggs were exposed for 48 h to
water containing either acetone or a range of concentrations of [
super(3)H]TCDD dissolved in acetone. Eggs were then transferred to
TCDD-free water and observed through development. TCDD
concentrations of 101 to 470 pg/g in the eggs caused dose-related
increases in sac-fry mortality associated with yolk-sac edema,
hemorrhages, and arrested development. These signs of TCDD-induced
toxicity resemble blue-sac disease. The NOELs and LOELs for
sac-fry mortality were 135 and 185 pg TCDD/g egg, respectively,
whereas the LD50 and LD100 (95% fiducial limits) were 200
(179-215) and 324 (283-488) pg/g egg, respectively. The time
course and signs of TCDD toxicity to brook trout during early
development are essentially identical to those observed in both
rainbow trout and lake trout following TCDD exposure of their eggs
via water or injection, and in lake trout exposed to maternally
derived TCDD. Brook trout sac fry are intermediate in sensitivity
to TCDD-induced lethality compared to lake trout and rainbow
trout.
 Descriptors: Environmental Engineering | Tetrachlorodibenzo-p-dioxin | Brook trout | Developmental toxicity | Blue sac disease | Sac fry
mortality | Egg | Early life stage | Acetone | High performance liquid
chromatography | Aromatic hydrocarbons | Environmental impact | Toxicity | Diseases | Hazardous materials | Water | Water pollution
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