 |
|
|
 |
|
 |
| |
Welcome to ProQuest-CSA, your Guide to Discovery. ProQuest-CSA helps researchers worldwide find and manage relevant information in their field. If you're a member of an academic institution you may have access to CSA Illumina. Please contact your library to find out. |
|
 |
|
 |
|
Efficacy and safety of electroconvulsive therapy in depressive
disorders: a systematic review and meta-analysis
Geddes, J
Lancet [Lancet]. Vol. 361, no. 9360, pp. 799-808. 8 Mar 2003.
We aimed to review published work for the efficacy and safety of
electroconvulsive therapy (ECT) with simulated ECT, ECT versus
pharmacotherapy, and different forms of ECT for patients with
depressive illness. We designed a systematic overview and
meta-analysis of randomised controlled trials and observational
studies. We obtained data from the Cochrane Collaboration
Depressive Anxiety and Neurosis and Schizophrenia Group Controlled
trial registers, Cochrane Controlled Trials register, Biological
Abstracts, CINAHL, EMBASE, LILACS, MEDLINE, PsycINFO, and SIGLE,
reference lists, and specialist textbooks. Our main outcome
measures were depressive symptoms, measures of cognitive function,
and mortality. Meta-analysis of data of short-term efficacy from
randomised controlled trials was possible. Real ECT was
significantly more effective than simulated ECT (six trials, 256
patients, standardised effect size [SES] -0.91, 95% CI -1.27 to
-0.54). Treatment with ECT was significantly more effective than
pharmacotherapy (18 trials, 1144 participants, SES -0.80, 95% CI
-1.29 to -0.29). Bilateral ECT was more effective than unipolar
ECT (22 trials, 1408 participants, SES -0.32, 95% CI -0.46 to
-0.19). ECT is an effective short-term treatment for depression,
and is probably more effective than drug therapy. Bilateral ECT is
moderately more effective than unilateral ECT, and high dose ECT
is more effective than low dose.
 Descriptors: Article Subject Terms Dose-response effects | Reviews | Risk assessment | Side
effects
|
|
|
|
