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TOXLINE on this service offers rapid access to information in all areas of toxicology, including chemicals and pharmaceuticals, pesticides, environmental pollutants, and mutagens and teratogens. This database, produced by the U.S. National Library of Medicine, provides bibliographic citations and abstracts from the core journal literature in toxicology. This version of TOXLINE does not contain information from Chemical Abstracts Service, BIOSIS, or International Pharmaceutical Abstracts.
Subject Coverage
    Major areas of coverage include:
    • Air pollution
    • Antidotes
    • Biological and adverse effects of drugs
    • Carcinogenesis via chemicals
    • Chemically-induced diseases
    • Environmental chemicals and pollutants
    • Food additives
    • Genotoxicity
    • Hazardous materials
    • Health and safety
    • Human and animal toxicity
    • Industrial and household chemicals
    • Mutagenicity Pesticides and herbicides
    • Radioactive materials
    • Risk information
Dates of Coverage
    2000 - current
Update Frequency
    Over 0 records as of May 2013
    U.S. National Library of Medicine
    National Institute of Health
    8600 Rockville Pike
    Bethesda, MD 20894
    Voice: +1 301-496-7706
    Fax: +1 301-496-0822
Sample Record
    TI: Title
    Relationship of serum TCDD concentrations and age at exposure of female residents of Seveso, Italy.
    AU: Author
    Eskenazi, B; Mocarelli, P; Warner, M; Needham, L; Patterson, DG Jr; Samuels, S; Turner, W; Gerthoux, PM; Brambilla, P
    AF: Author Affiliation
    School of Public Health, University of California at Berkeley, 2150 Shattuck Avenue, Berkeley, CA 94720-7380, USA.
    SO: Source
    Environmental health perspectives, 2004 Jan, 112(1):22-7
    IS: ISSN
    AB: Abstract
    In 1976, a chemical plant explosion near Seveso, Italy, resulted in the highest known exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in residential populations. In 1996, we initiated the Seveso Women's Health Study (SWHS), a historical cohort study of females who were 40 years old at the time of explosion and residents of the most heavily contaminated areas, zones A and B. Serum samples collected near the time of the explosion were analyzed for TCDD. We also analyzed pooled serum samples collected in 1976 from females who resided in zone non-ABR, the "unexposed" zone, to assess concurrent background exposures to other dioxins, furans, and coplanar polychlorinated biphenyls (PCBs). The median lipid-adjusted TCDD level for residents of zones A and B combined was 56 ppt (range = 2.5-56,000 ppt). Zone A residents had 5-fold higher TCDD levels (n = 67, median = 272 ppt) than did zone B residents (n = 814, median = 47 ppt). The youngest children had the highest TCDD levels, which decreased with age at explosion until approximately 13 years of age and were constant thereafter. Therefore, children living in zones A and B received a disproportionately higher exposure to TCDD as a result of the explosion. Zone of residence and age were the strongest predictors of TCDD level. Chloracne, nearby animal mortality, location (outdoors vs. indoors) at the time of explosion, and consumption of homegrown food were also related to serum TCDD levels. The serum pools from zone non-ABR residents had an average TCDD concentration of 20.2 ppt, and average total toxic equivalent (TEQ) concentration of 100.4 ppt. Therefore, background exposure to dioxins, furans, and PCBs unrelated to the explosion may have been substantial. As a consequence, previous SWHS studies that considered only TCDD exposure may have underestimated health effects due to total TEQ concentrations.
    LA: Language
    PY: Publication Year
    PT: Publication Type
    Journal Article
    DE: Descriptors
    Accidents, Occupational; Adolescent; Adult; Age Factors; Chemical Industry; Child; Child Welfare; Child, Preschool; Cohort Studies; Diet; Environmental Exposure; Explosions; Female; Food Contamination; Human; Infant; Infant, Newborn; Italy; Risk Assessment; Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.; Teratogens: analysis; Tetrachlorodibenzodioxin: blood
    RN: Registry Number
    0 (Teratogens); 1746-01-6 (Tetrachlorodibenzodioxin)
    GI: Grant
    Grant/Contract ID: 2P30 ES 001896-17 (NIEHS); R01 ES 07171 (NIEHS)
    UD: Update
    RO: Record Owner
    National Library of Medicine
    AN: Accession Number
Field Codes
    The following field codes are found in the records of this database. Here they are listed in alphabetical order by two-letter code. See Field Codes and Search Examples for detailed descriptions and search examples.

    AB = Abstract LA = Language
    AF = Author Affiliation LR = Last Revision Date
    AN = Accession Number NT = Notes
    AU = Author OT = Original Title
    CP = Country of Publication PT = Publication Type
    DB = Databank PY = Publication Year
    DE = Descriptors RN = Registry Number
    EE = Electronic Publication Date RO = Record Owner
    FE = Features RP = Report Number
    GI = Grant Information SF = Subfile
    ID = Identifiers SM = Space Flight Mission
    IR = Investigator SO = Source
    IS = ISSN TI = Title
    JN = Journal Name UD = Update